Extensive crustal anatexis is common during the decompressional exhumation of deeply subducted continental crust and the delamination of a collision-thickened orogenic lithosphere, indicating that determining the timing of partial melting can provide insights into the possible tectonic evolution during orogenic processes. An integrated study of petrology, zirconology and whole-rock geochemical compositions from migmatites and pegmatites in the Nageng, Langmuri and Wulonggou area of the East Kunlun orogenic belt, is presented in this study. The protoliths of these migmatites include Tonian sedimentary rocks and ca. 440 Ma arc-related dioritic rock. Together with previous studies, an extensive crustal anatexis event recorded by anatectic zircons occurred after ca. 410 Ma. In addition, hafnium isotope analyses indicate that the anatectic zircons may or may not inherit their Hf isotope compositions from protolith zircons during partial melting, depending on whether or not the garnet Hf contributes to the Hf budget of anatectic melt. Thus, the most reasonable method to trace the source of granite is to compare the Hf isotope composition of anatectic zircon in migmatite and magmatic zircon in contemporaneous granite. By such method, anatectic melt produced by migmatites in this study could account for both penecontemporaneous A- and I-type granites with high magmatic zircon εHf(t) values and S-type granites with low magmatic zircon εHf(t) values. As the extensive crustal anatexis is later than both metamorphic peak and amphibole-facies retrogression of high-pressure and ultrahigh-pressure (HP-UHP) metamorphic rocks, it is reasonable that post-collision orogenic collapse of the collisionthickened orogenic lithosphere as a result of delamination and asthenospheric upwelling occurred after ca. 410 Ma, which is also supported by contemporaneous granulite-facies metamorphism, molasse deposition, and magmatic events including Xiarihamu mafic-ultramafic intrusions, A-type granites, and mafic dykes formed in the continental rifting setting.